siRNA Delivery Challenges |
| The challenges of systemic siRNA delivery are well documented and include numerous biological barriers that limit siRNAs from reaching their “target” safely and effectively. |
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Specifically, negatively-charged natural or modified siRNAs are typically unable to be internalized inside the cell to reach their target in the cell cytoplasm. This limitation has created a major hurdle for companies currently working toward the advancement of systemic RNAi therapeutics – the sustained systemic delivery of siRNA to the target tissue. Without a means to selectively and effectively achieve targeted tissue and intracellular delivery of siRNA molecules, it will be impossible to unlock the full therapeutic potential of this exciting new class of drugs.