SCIENCE OF RNAi
Paradigm Advantages
Existing Paradigm |
siRNA Paradigm |
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| Drugs/MOA | Small molecules, MoAb/Antagonists | siRNAs in a delivery vehicle/Silencing | |
| Targets | Mainly extracellular targets (Abs) | All targets | |
| Selectivity and Potency |
Usually low (small molecules) | Highly selective and potent | |
| Time to lead ID & Optimization |
Long (several years) | Short (few months) | |
| Risk | Usually high (small molecules) | Low (following POC of delivery vehicle) |