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Intradigm Corporation Scientific Publications

Frank Y. Xie, Martin C. Woodle and Patrick Y. Lu, Harnessing In Vivo siRNA Delivery For Target Validation And Therapeutic Development. Drug Discovery Today, 2006 Jan;11(1-2):67-73. Review.

Bao-jian Li, Qingquan Tang, Du Cheng, Chuan Qin, Frank Y Xie, Qiang Wei, Jun Xu, Yijia Liu, Bo-jian Zheng, Martin C Woodle, Nanshan Zhong & Patrick Y Lu. Using siRNA for prophylactic and therapeutic regimens against SARS coronavirus in Rhesus Macaque. Nature Medicine, 2005 Aug. 11(8).

Woodle, MC and PY Lu, Nanoparticles deliver RNAi therapy. Material Today/ Nanotoday, 2005 Aug; 8(8):34-41,

Schiffelers RM, Xu J, Storm G, Woodle MC, Scaria PV. Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis Rheum. 2005 Apr;52(4):1314-8.

Lu PY, Xie FY, Woodle MC. Modulation of angiogenesis with siRNA inhibitors for novel therapeutics. Trends Mol Med. 2005 Mar; 11(3):104-13.

Kim B, Tang Q, Biswas PS, Xu J, Schiffelers RM, Xie FY, Ansari AM, Scaria PV, Woodle MC, Lu P, Rouse BT. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol. 2004 Dec;165(6):2177-85.

Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 2004 Nov 1;32 (19):e149.

Xie, FY, Liu, Y, Xu, J, Tang, QQ., Scaria, PV, Zhou, Q, Woodle, MC, and Lu, PY. Delivering siRNA to Animal Disease Models for Validation of Novel Drug Targets In Vivo. PharmaGenomics, 2004 July/Aug, 28-38.

Lu PY, Xie FY, Woodle MC. siRNA-mediated antitumorigenesis for drug target validation and therapeutics. Curr Opin Mol Ther. 2003 Jun; 5(3):225-34.